Skip to content
IMSI / PICSI — Advanced Sperm Selection
IVF

IMSI / PICSI — Advanced Sperm Selection

Specialist physician: Assist. Prof. Dr. Muzaffer Uçarer — Obstetrics & Gynaecology · IVF and Reproductive Medicine  ·  Last updated: September 2026
This page provides general information and does not replace a medical consultation. Please consult your physician about your individual situation.

PICSI and IMSI are advanced sperm-selection techniques used in IVF when sperm quality, morphology or DNA fragmentation is a concern. The method we use at UCARER is PICSI: it selects mature sperm by their natural ability to bind hyaluronic acid — the same binding that happens around the egg in nature. Your embryologist decides, cycle by cycle, whether it is likely to add value. In the largest randomised trial to date (HABSelect, 2,772 couples) PICSI lowered the miscarriage rate; a higher live-birth rate for every couple was not demonstrated. IMSI is a separate technique that relies on ultra-high magnification alone.

Prices

  • Included in every IVF package — no extra charge

Our medical prices are fixed; your exact, all-inclusive price is confirmed in writing after your consultation. See our full price list →

Contact UCARER Women’s Health to book your consultation with Assist. Prof. Dr. Muzaffer Uçarer.

Explore More

Frequently Asked Questions

Common Questions

Most often after a previous IVF failure, poor embryo development, recurrent miscarriage, or abnormal sperm morphology and DNA fragmentation results. The embryology team makes the call on the day of the procedure, based on the fresh sample.

All three involve injecting a single sperm into the egg. IMSI relies on ultra-high magnification; PICSI adds a biological selection step based on the sperm's maturity. PICSI is the method used in our laboratory, alongside SpermChip microfluidic selection.

Yes. It is an established laboratory step carried out by experienced embryologists. It does not change the ICSI procedure itself — only which sperm is chosen for it.

No, and we will not claim that it does. In the largest randomised trial (HABSelect, 2,772 couples) PICSI reduced miscarriage; a higher live-birth rate for everyone was not shown. Among the sperm-selection methods offered in IVF today, PICSI is the one with randomised-trial evidence behind it.

No. PICSI is included in every UCARER IVF package at no extra cost, together with SpermChip microfluidic sperm selection.

Book Your Appointment Today

We provide a comfortable environment where you can consult us with all your problems in the field of Obstetrics, Gynecology and IVF Treatment.

Book Now Chat on WhatsApp Chat on Telegram